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Updated mutation overview

posted Jan 13, 2014, 5:49 AM by Albert Kooistra   [ updated Jan 13, 2014, 5:54 AM ]
For our British Journal of Pharmacology publication regarding the structural chemogenomics analysis of aminergic GPCRs (publication) we created
 a comprehensive overview of all site-directed mutagenesis studies performed against HRH1, HRH2, HRH3, HRH4, DRD3, ACM2, ACM3, ADRB1 and ADRB2 (aminergic GPCRs). In total 1420 reported single-point mutations were registered (including their effect on the binding affinity of reported ligands) at 128 individual B&W positions. 

We have now updated this comprehensive overview and incorporated ChEMBL identifiers for each of the ligands, the ligand structure in SMILES format and PUBMED identifiers. This update makes it easier to link the ligands to known activity/affinity data (ChEMBL), investigate the ligand structure, and to go back to the original publication in which the mutation data was published (PUBMED). 

Download this updated overview here.